全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM01939G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD79A Antibody (clone HM57).
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分子量 |
25kDa
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse, Rat, Rabbit, Pig, Chicken, Opossum, Horse, Bovine, Guinea Pig
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靶點 |
The antibody HM57 interacts with CD79a (Ig alpha), a 40-45 kD subunit of B cell antigen-specific receptor (BCR) and its early developmental forms. HLDA V; WS Code BC cB018. HLDA VI; WS Code BP 193. HLDA VI; WS Code BP 89. HLDA VI; WS Code B B103. HLD ...
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克隆號 |
HM57
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通用名 |
IGA, MB1
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基因ID |
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UniProt ID |
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功能 |
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
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總結(jié) |
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC-P, IHC-Fr, Flo
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稀釋方法 |
IHC-Fr, IHC-P (15 μg/ml),
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圖像 |
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說明書 |
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數(shù)量 |
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