PTPRC Antibody

AMM02963G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM02963G		100 μl / ￥4950

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PTPRC Antibody

品牌	Leading Biology	貨號(hào)	AMM02963G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PTPRC Antibody.
分子量	147.3kDa
細(xì)胞定位	Antigen Cellular Localization: Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts
宿主	Mouse
種屬反應(yīng)性	Human
克隆號(hào)	2C10C11
亞型	IgG1
通用名	CD45
基因ID	5788
UniProt ID	P08575
功能	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
總結(jié)	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. ; ; ;
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, E
稀釋方法	E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000
圖像	Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Figure 1: Western blot analysis using PTPRC mAb against human PTPRC (AA: 928-989) recombinant protein. (Expected MW is 33 kDa) Figure 2: Western blot analysis using PTPRC mAb against HEK293 (1) and PTPRC (AA: 928-989)-hIgGFc transfected HEK293 (2) cell lysate.
說(shuō)明書(shū)	Product Datasheet Protocol
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