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F8 Antibody (monoclonal) (M03)

AMM03510G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM03510G		100 μg / ￥4950

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F8 Antibody (monoclonal) (M03)

品牌	Leading Biology	貨號	AMM03510G
產(chǎn)品分類	Monoclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality F8 Antibody (monoclonal) (M03).
分子量	267009 Da
宿主	mouse
種屬反應性	Human
靶點	F8 (NP_000123, 213 a.a. ~ 312 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
克隆號	1.00E+09
亞型	IgG2b Kappa
基因ID	2157
UniProt ID	P00451
總結	This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	E
圖像	Detection limit for recombinant GST tagged F8 is approximately 3ng/ml as a capture antibody. Proximity Ligation Analysis of protein-protein interactions between CALR and F8. HeLa cells were stained with anti-CALR rabbit purified polyclonal 1:1200 and anti-F8 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
說明書	Product Datasheet Protocol
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