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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > GITR / Tnfrsf18 (mouse) Antibody - Without BSA and Azide品牌 |
Leading Biology | 貨號 |
AMRa00008G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GITR / Tnfrsf18 (mouse) Antibody - Without BSA and Azide.
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分子量 |
66-70kDa (Homodimer)
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細(xì)胞定位 |
Antigen Cellular Localization:
Isoform A: Cell membrane; Single-pass type I membrane protein Isoform C: Cell membrane; Single-pass type I membrane protein
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宿主 |
Rat
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種屬反應(yīng)性 |
Mouse
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克隆號 |
DTA-1
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亞型 |
Rat / IgG2b, lambda
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通用名 |
Gitr
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基因ID |
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UniProt ID |
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功能 |
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).
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總結(jié) |
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+?CD4+?Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-??B activation, and abrogate the inhibitory function of?CD25+?CD4+?Tregs. In vivo?activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IF, FC
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說明書 |
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數(shù)量 |
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