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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > CD14 (Monocyte / Macrophage Marker) Antibody - Without BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM01498G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD14 (Monocyte / Macrophage Marker) Antibody - Without BSA and Azide.
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分子量 |
55kDa
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號 |
LPSR/553
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亞型 |
Mouse / IgG1, kappa
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基因ID |
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UniProt ID |
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功能 |
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
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總結(jié) |
Recognizes a protein of 55kDa, identified as CD14 (also known lipopolysaccharide receptor). CD14 is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IF, FC
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說明書 |
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數(shù)量 |
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