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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - Without BSA and Azide品牌 |
Leading Biology | 貨號(hào) |
AMM01227G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - Without BSA and Azide.
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分子量 |
12kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Secreted. Note=Detected in serum and urine
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號(hào) |
C21.48A1
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亞型 |
Mouse / IgG2b, kappa
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基因ID |
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UniProt ID |
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功能 |
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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總結(jié) |
The antibody recognizes the hidden determinant of β-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. β-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum β2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. β2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IF, FC
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說明書 |
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數(shù)量 |
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