總結(jié) |
Recognizes a protein of 12kDa, identified as ?? ??€ ??€ ?microglobulin. Beta-?€ ?-microglobulin non-covalently associates with the 44kDa ??? chain to form the HLA Class I antigen complex. Human?€?? ?eta-?€ ?-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. This MAb is specific to human?€?? ??€ ?-microglobulin and does not react with non-human primate cells. This antibody reacts with all cell types excluding erythrocytes. The detection of ??2?microglobulin in body fluids has been used as a tumor marker and for monitoring patients with HIV infection.
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