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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > CD47 / IAP (Integrin Associated Protein) Antibody - Without BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM00481G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD47 / IAP (Integrin Associated Protein) Antibody - Without BSA and Azide.
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分子量 |
~50kDa
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse
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克隆號 |
B6H12.2
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亞型 |
Mouse / IgG1, kappa
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通用名 |
MER6
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基因ID |
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UniProt ID |
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功能 |
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
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總結(jié) |
This antibody reacts with Ig domain of CD47 protein. It has been shown to inhibit polymorphonuclear neutrophil (PMN) transmigration across cell monolayers and matrix. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus.? CD47 may play a role in membrane transport and/or integrin dependent signal transduction.?
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC-P, IF, FC
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說明書 |
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數(shù)量 |
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