von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - Without BSA and Azid

AMM00429G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM00429G		100 μg / ￥4950

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von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - Without BSA and Azid

品牌	Leading Biology	貨號	AMM00429G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - Without BSA and Azid.
分子量	250kDa
細(xì)胞定位	Antigen Cellular Localization: Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules
宿主	Mouse
種屬反應(yīng)性	Human
克隆號	VWF635
亞型	Mouse / IgG1, kappa
通用名	F8VWF
基因ID	7450
UniProt ID	P04275
功能	Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
總結(jié)	von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposiā€?s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.
形式	Liquid
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, FC, IP
圖像	Formalin-fixed, paraffin-embedded human Bone Marrow stained with vWF Monoclonal Antibody (VWF635) Formalin-fixed, paraffin-embedded human Tonsil stained with vWF Monoclonal Antibody (VWF635)
說明書	Product Datasheet Protocol
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von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - Without BSA and Azid