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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > c-Myc Oncoprotein Antibody - Without BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM00347G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality c-Myc Oncoprotein Antibody - Without BSA and Azide.
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分子量 |
62-64kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus, nucleoplasm. Nucleus, nucleolus
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號 |
MYC275
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亞型 |
Mouse / IgG1, kappa
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通用名 |
BHLHE39
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基因ID |
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UniProt ID |
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功能 |
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes.
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總結(jié) |
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC-P, IF, FC
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圖像 |
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說明書 |
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數(shù)量 |
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