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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > p21WAF1 (Tumor Suppressor Protein) Antibody - Without BSA and Azide

p21WAF1 (Tumor Suppressor Protein) Antibody - Without BSA and Azide

貨號 貨期 規(guī)格 / 價格 詢價
AMM00213G 100 μg / ¥4950

p21WAF1 (Tumor Suppressor Protein) Antibody - Without BSA and Azide

品牌

Leading Biology

貨號

AMM00213G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality p21WAF1 (Tumor Suppressor Protein) Antibody - Without BSA and Azide.

分子量

21kDa

細胞定位

Antigen Cellular Localization: Cytoplasm. Nucleus.

宿主

Mouse

種屬反應性

Human, Mouse, Rat, Monkey, Chimpanzee

克隆號

WA-1

亞型

Mouse / IgG1, kappa

通用名

CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WA

基因ID

UniProt ID

功能

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

總結(jié)

This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma). In ELISA, MAb WA-1 is useful either as a solid phase or for detection of p21 protein.

形式

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應用

IHC-P, IF, FC

圖像

Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with p21 Monoclonal Antibody (WA-1).

說明書

數(shù)量

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