CD8A (Cytotoxic- & Suppressor T-Cell Marker) Antibody

AMM01485G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM01485G		7 ml / ￥4950

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CD8A (Cytotoxic- & Suppressor T-Cell Marker) Antibody

品牌	Leading Biology	貨號(hào)	AMM01485G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CD8A (Cytotoxic- & Suppressor T-Cell Marker) Antibody.
分子量	32kDa
細(xì)胞定位	Antigen Cellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein
宿主	Mouse
種屬反應(yīng)性	Human
克隆號(hào)	C8/468
亞型	Mouse / IgG1, kappa
通用名	MAL
基因ID	925
UniProt ID	P01732
功能	Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
總結(jié)	CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-F, IF, FC, IP
圖像	Formalin-fixed, paraffin-embedded human Tonsil stained with CD8 Monoclonal Antibody (C8/468).
說(shuō)明書(shū)	Product Datasheet Protocol
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