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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody品牌 |
Leading Biology | 貨號 |
AMM01228G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody.
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分子量 |
12kDa
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細胞定位 |
Antigen Cellular Localization:
Secreted. Note=Detected in serum and urine
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號 |
B2M/961
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亞型 |
Mouse / IgG2b, kappa
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基因ID |
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UniProt ID |
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功能 |
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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總結(jié) |
Recognizes a protein of 12kDa, identified as β-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC, IF, FC
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圖像 |
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說明書 |
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數(shù)量 |
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