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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Progesterone Receptor (Marker of Progestin Dependence) Antibody品牌 |
Leading Biology | 貨號 |
AMM01200G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Progesterone Receptor (Marker of Progestin Dependence) Antibody.
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分子量 |
PR-A (81kDa) and PR-B (116kDa).
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細胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane
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宿主 |
Mouse
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種屬反應性 |
Human
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克隆號 |
PR484
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亞型 |
Mouse / IgG1, kappa
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通用名 |
NR3C3
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基因ID |
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UniProt ID |
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功能 |
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
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總結(jié) |
This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
IHC
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圖像 |
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說明書 |
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數(shù)量 |
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