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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > FOXP3 (Forkhead Box Protein P3) / Scurfin Antibody品牌 |
Leading Biology | 貨號 |
AMM01169G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FOXP3 (Forkhead Box Protein P3) / Scurfin Antibody.
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分子量 |
47-55kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089}
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse, Monkey
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克隆號 |
SPM579
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亞型 |
Mouse / IgG1, kappa
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通用名 |
IPEX
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基因ID |
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UniProt ID |
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功能 |
Probable transcription factor. Plays a critical role in the control of immune response.
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總結(jié) |
Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC, IF, FC
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圖像 |
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說明書 |
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數(shù)量 |
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