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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > EMI1 (Early Mitotic Inhibitor-1) Antibody

EMI1 (Early Mitotic Inhibitor-1) Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM00743G 7 ml / ￥4950

EMI1 (Early Mitotic Inhibitor-1) Antibody

品牌

 Leading Biology

貨號(hào)

 AMM00743G

產(chǎn)品分類

 Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EMI1 (Early Mitotic Inhibitor-1) Antibody.

分子量
56kDa

細(xì)胞定位
Antigen Cellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle

宿主
Mouse

種屬反應(yīng)性
Human

克隆號(hào)
EMI1/1176

亞型
Mouse / IgG2a, kappa

通用名
EMI1, FBX5

基因ID

UniProt ID

功能
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.

總結(jié)
It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

形式
Liquid

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC, IF, FC

圖像

Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with EMI1 Monoclonal Antibody (EMI1/1176).

Formalin-fixed, paraffin-embedded human Ovarian carcinoma stained with EMI1 Monoclonal Antibody (EMI1/1176).

說明書

數(shù)量

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