全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM02500G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PRL3 Antibody.
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分子量 |
19535 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane. Early endosome
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Mouse
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靶點(diǎn) |
This monoclonal antibody is generated from mice immunized with a recombinant protein.
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克隆號 |
111AT714
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亞型 |
Mouse IgG1
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通用名 |
PRL3
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基因ID |
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UniProt ID |
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功能 |
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
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總結(jié) |
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:100~500
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圖像 |
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說明書 |
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數(shù)量 |
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