全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM02413G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HGF Antibody.
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分子量 |
83134 Da
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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免疫原 |
521-554 aa
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靶點 |
This HGF antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 521-554 amino acids from human HGF.
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克隆號 |
489CT6.12.6
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亞型 |
IgG1
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通用名 |
HPTA
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基因ID |
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UniProt ID |
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功能 |
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
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總結(jié) |
Hepatocyte growth factor regulates cell growth, cellmotility, and morphogenesis by activating a tyrosine kinasesignaling cascade after binding to the proto-oncogenic c-Metreceptor. Hepatocyte growth factor is secreted by mesenchymal cellsand acts as a multi-functional cytokine on cells of mainlyepithelial origin. Its ability to stimulate mitogenesis, cellmotility, and matrix invasion gives it a central role inangiogenesis, tumorogenesis, and tissue regeneration. It issecreted as a single inactive polypeptide and is cleaved by serineproteases into a 69-kDa alpha-chain and 34-kDa beta-chain. Adisulfide bond between the alpha and beta chains produces theactive, heterodimeric molecule. The protein belongs to theplasminogen subfamily of S1 peptidases but has no detectableprotease activity. Alternative splicing of this gene producesmultiple transcript variants encoding different isoforms. [providedby RefSeq].
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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