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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM01493G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide.
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分子量 |
32kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Cell membrane; Single-pass type I membrane protein Isoform 7: Secreted.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號 |
BU88
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亞型 |
Mouse / IgG1, kappa
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通用名 |
CD8B1
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基因ID |
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UniProt ID |
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功能 |
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
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總結(jié) |
The T cell receptor (TCR) is a heterodimer composed of either ? ? and ? ? or ? ? and ? ? chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD8 (also designated Leu 2 or T8), a cell surface glycoprotein, is a two chain complex (? ?-? ? or ? ?-? ?) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IF, FC
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說明書 |
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數(shù)量 |
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