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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - With BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM01022G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - With BSA and Azide.
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分子量 |
195kDa (intact); 80kDa (cleaved)
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號 |
2F6
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亞型 |
Mouse / IgG2a, kappa
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通用名 |
MAPKKK1, MEKK, MEKK1
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基因ID |
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UniProt ID |
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功能 |
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
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總結(jié) |
Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NF??B pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, IF, FC
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圖像 |
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說明書 |
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數(shù)量 |
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