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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > Cytokeratin 14 (KRT14) (Squamous Cell Marker) Antibody - With BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM00974G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Cytokeratin 14 (KRT14) (Squamous Cell Marker) Antibody - With BSA and Azide.
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分子量 |
50kDa
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern
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宿主 |
Mouse
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種屬反應性 |
Human, Rat, Cat
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克隆號 |
KRT14/284
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亞型 |
Mouse / IgG2b, kappa
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基因ID |
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UniProt ID |
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功能 |
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
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總結(jié) |
Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
IF, FC
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說明書 |
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數(shù)量 |
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