EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide

AMM00744G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM00744G		50 ug / ￥3950

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EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide

品牌	Leading Biology	貨號	AMM00744G
產(chǎn)品分類	Monoclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide.
分子量	56kDa
細胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle
宿主	Mouse
種屬反應性	Human
克隆號	EMI1/1176
亞型	Mouse / IgG2a, kappa
通用名	EMI1, FBX5
基因ID	26271
UniProt ID	Q9UKT4
功能	Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
總結	It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
形式	Liquid
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IHC, IF, FC
圖像	Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with EMI1 Monoclonal Antibody (EMI1/1176). Formalin-fixed, paraffin-embedded human Ovarian carcinoma stained with EMI1 Monoclonal Antibody (EMI1/1176).
說明書	Product Datasheet Protocol
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EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide