MALT1 (MALT-Lymphoma Marker) Antibody - With BSA and Azide

AMM00228G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM00228G		50 ug / ￥3950

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MALT1 (MALT-Lymphoma Marker) Antibody - With BSA and Azide

品牌	Leading Biology	貨號(hào)	AMM00228G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MALT1 (MALT-Lymphoma Marker) Antibody - With BSA and Azide.
分子量	93kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10
宿主	Mouse
種屬反應(yīng)性	Human
克隆號(hào)	SPM578
亞型	Mouse / IgG1, kappa
通用名	MLT
基因ID	10892
UniProt ID	Q9UDY8
功能	Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
總結(jié)	Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
形式	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, FC
圖像	Formalin-fixed, paraffin-embedded human Tonsil stained with MALT1 Monoclonal Antibody (SPM578)
說明書	Product Datasheet Protocol
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MALT1 (MALT-Lymphoma Marker) Antibody - With BSA and Azide