Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide

AMM00195G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM00195G		50 ug / ￥3950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide

品牌	Leading Biology	貨號(hào)	AMM00195G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide.
分子量	55-62kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
宿主	Mouse
種屬反應(yīng)性	Human, Mouse, Hamster
靶點(diǎn)	Hamster Cyclin B1 protein
克隆號(hào)	V92.1
亞型	IgG1, kappa
通用名	CCNB
基因ID	891
UniProt ID	P14635
功能	Essential for the control of the cell cycle at the G2/M (mitosis) transition.
總結(jié)	It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
形式	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, IF, FC, IP, E
說(shuō)明書(shū)	Product Datasheet Protocol
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