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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > MAGE-1 (Target for Cancer Immunotherapy) Antibody - With BSA and Azide品牌 |
Leading Biology | 貨號 |
AMM00161G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MAGE-1 (Target for Cancer Immunotherapy) Antibody - With BSA and Azide.
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分子量 |
42-46kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus.
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Rat, Dog
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靶點(diǎn) |
Human MAGE-A1 full length recombinant protein
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克隆號 |
MA454
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亞型 |
IgG1, kappa
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通用名 |
MAGE1, MAGE1A
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基因ID |
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UniProt ID |
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功能 |
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
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總結(jié) |
Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, FC, IP, E
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圖像 |
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說明書 |
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數(shù)量 |
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