品牌 |
Leading Biology |
貨號(hào) |
LM21163 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
|
產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
|
形式 |
Novel non-receptor tyrosine-protein kinase, Tyk2, belongs to the tyrosine protein kinase family and plays a role in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Tyk2 is believed to phosphorylate the interferon-alpha/beta receptor alpha chain (1). It has been shown that Tyk2 links the interferon alpha/beta receptor to the cytoplasmic transcription factor that mediates activation of interferon-responsive genes (2).
|
濃度 |
A synthetic peptide corresponding to residues near the C-terminus of human Tyk2 was used as an immunogen. |
純度 |
Rabbit |
試劑準(zhǔn)備 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
|
復(fù)溶 |
1. Firmback-Kraft I, et al. Oncogene 5(9):1329-36, 1990.<br>2. Velazquez L, et al. Cell 70(2):313-22, 1992.<br>
|
儲(chǔ)存條件 |
Human, Mouse, Rat
|
儲(chǔ)存溶液 |
Non-receptor tyrosine-protein kinase TYK2, TYK2
|
應(yīng)用 |
WB~~1:1000~5000
IHC~~1:100~250
|
產(chǎn)品描述 |
Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Tissue_Location
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines
|
數(shù)量 |
|