形式 |
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
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復(fù)溶 |
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. Choi YB, et al. J Biol Chem, 2010 Mar 5. PMID 20007709.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene. Lai RH, et al. Gene, 2009 Dec 1. PMID 19716864.
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儲存溶液 |
Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, CIS-4, Suppressor of cytokine signaling 4, SOCS-4, SOCS6, CIS4, SOCS4
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