全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
LM21031 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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形式 |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
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濃度 |
Mouse SOCS-1 |
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純度 |
Mouse |
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復(fù)溶 |
Minamoto S.,et al.Biochem. Biophys. Res. Commun. 237:79-83(1997).
Ohya K.,et al.J. Biol. Chem. 272:27178-27182(1997).
Starr R.,et al.Nature 387:917-921(1997).
Yandava C.N.,et al.Genomics 61:108-111(1999).
Schlueter G.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
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儲存條件 |
Human, Mouse
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儲存溶液 |
SOCS1, CIS1, CISH1, JAB, JAK-binding protein, JAK binding protein, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP3, SOCS-1, SSI1, STAT induced SH3 protein 1, TIP-3
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應(yīng)用 |
IHC-P (10 μg/ml), WB (1 - 10 μg/ml),
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產(chǎn)品描述 |
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Cellular_Location
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3
Tissue_Location
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes
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數(shù)量 |
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| 選擇 | 品牌 | 貨號 | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說明書 | 數(shù)量 | 目錄價(jià) | |
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| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 單克隆抗體 |
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| 5 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 μl | 單克隆抗體 | Antibodies against components of the renin-angiotensin system |
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￥5096.00 | 訂購 詢價(jià) |
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