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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > 單克隆抗體 > OX40 Antibody

OX40 Antibody

LM20743
貨號 貨期 規(guī)格 / 價格 詢價

OX40 Antibody

品牌

Leading Biology

貨號

LM20743

產(chǎn)品分類

單克隆抗體

研究領域

產(chǎn)品概述

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

形式

Tumor necrosis factor receptor superfamily member 4 (OX40, CD134) is a membrane receptor found on activated CD4+ and CD8+ T cells and B cells (1). OX40 binds to OX40 ligand (OX40L) and other TNF receptor-associated factors (TNAF2, TRAF3, TRAF5). OX40-OX40L complex produces CD28 independent co-stimulatory signals. OX40 is involved in the pathologic cytokine storm associated in certain viral infection, such as H4N1 bird flu. OX40 starts a survival signal to the T-cell preventing activation-induced apoptosis, but up regulates cytokine production. Inhibition of OX40 using OX40-immunoglobulin has been linked to reduction of immune overreaction without affecting the viral clearance (2).

濃度

A synthetic peptide corresponding extracellular domain of human OX40 was used as an immunogen.

純度

Rabbit

試劑準備

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

復溶

1. Gramaglia I, et al. Immunol 161:6510-6517, 1998.<br>2. Humphreys IR, et al. JEM 198:1237-1242, 2003<br>

儲存條件

Human

儲存溶液

Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, CD252, TNFSF4, TXGP1

應用

WB~~1:500

產(chǎn)品描述

Function Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Cellular_Location Membrane; Single-pass type II membrane protein

數(shù)量

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