Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

This gene encodes a member of the unconventional myosinprotein family, which are actin-based molecular motors. The proteinis found in the cytoplasm, and one isoform with a unique N-terminusis also found in the nucleus. The nuclear isoform associates withRNA polymerase I and II and functions in transcription initiation.The mouse ortholog of this protein also functions in intracellularvesicle transport to the plasma membrane. Multiple transcriptvariants encoding different isoforms have been found for this gene.The related gene myosin IE has been referred to as myosin IC in theliterature, but it is a distinct locus on chromosome 19. [providedby RefSeq].

This MYO1C monoclonal antibody is generated from mouse immunized with MYO1C recombinant protein.

Mouse

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Obrdlik, A., et al. FASEB J. 24(1):146-157(2010) Zadro, C., et al. Biochim. Biophys. Acta 1792(1):27-32(2009) Laakso, J.M., et al. Science 321(5885):133-136(2008) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : Olsen, J.V., et al. Cell 127(3):635-648(2006)

Human

Unconventional myosin-Ic, Myosin I beta, MMI-beta, MMIb, MYO1C

WB~~1:100~500

Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Cellular_Location Isoform 1: Cytoplasm. Nucleus. Note=Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level.