全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
LM20495 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
IRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5).
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濃度 |
A synthetic peptide corresponding to residues in the C-term of human IRAK-3 was used as immunogen. |
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純度 |
Rabbit |
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試劑準(zhǔn)備 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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復(fù)溶 |
1. Cao, Z., W. J. Henzel, X. Gao. 1996. Science271:11282.<br>2. Kanakaraj, P., K. Ngo, Y. Wu, A. Angulo, P. Ghazal, C. A. Harris, J. J. Siekierka, P. A. Peterson, W. P. Fung-Leung. 1999. J. Exp. Med.189:1129<br>3. H., Gao, X., Li, X., Kirschning, C.J., Stark, G.R. and Cao, Z., 1999. J. Biol. Chem. 274, pp. 19403<br>4. Muzio, M., Ni, J., Feng, P. and Dixit, V.M., 1997. Science 278, pp. 1612<br>5. Koichi Kobayashi, Lorraine D. Hernandez, Jorge E. Gal<br>
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儲(chǔ)存條件 |
Human
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儲(chǔ)存溶液 |
Interleukin-1 receptor-associated kinase 3, IRAK-3, IL-1 receptor-associated kinase M, IRAK-M, IRAK3 {ECO:0000312|EMBL:AAH578001}
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應(yīng)用 |
WB~~1:1000
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產(chǎn)品描述 |
Function
Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue_Location
Expressed predominantly in peripheral blood lymphocytes.
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數(shù)量 |
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| 選擇 | 品牌 | 貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說明書 | 數(shù)量 | 目錄價(jià) | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購 詢價(jià) | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 單克隆抗體 | Chondrogenesis Markers |
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| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 單克隆抗體 |
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￥3243.00 | 訂購 詢價(jià) | |||
| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 μl | 單克隆抗體 | Miscellaneous antibodies |
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￥3243.00 | 訂購 詢價(jià) | |
| 5 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 μl | 單克隆抗體 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 訂購 詢價(jià) | |
| 6 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購 詢價(jià) |
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