全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
LM20144 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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產(chǎn)品概述 |
Store at 2 to 8°C.Antibody is stable for 24 months.
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形式 |
Recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
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濃度 |
Recombinant human CD28 protein |
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純度 |
Mouse |
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試劑準(zhǔn)備 |
0.5 ml at 200ug/ml; Conjugated to AF488
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復(fù)溶 |
1. Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, King PD: Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. J Immunol. 2001;166(1):197-206.
2. Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D: Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol. 2004;24(9):3860-73.
3. Jeong SH, Qiao M, Nascimbeni M, Hu Z, Rehermann B, Murthy K, Liang TJ. Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates. J Virol. 2004;78(13):6995-7003.
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儲存條件 |
Human
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儲存溶液 |
T-cell-specific surface glycoprotein CD28, TP44, CD28, CD28
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產(chǎn)品描述 |
Function
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Cellular_Location
Membrane; Single-pass type I membrane protein
Tissue_Location
Expressed in T-cells and plasma cells, but not in less mature B-cells
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數(shù)量 |
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| 選擇 | 品牌 | 貨號 | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說明書 | 數(shù)量 | 目錄價 | |
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