濃度 |
Rat anti-Mouse CD122 antibody, clone TM-BETA 1 recognizes the murine CD122 cell surface glycoprotein, a ~75-85 kDa molecule also known as interleukin-2 receptor (IL-2R) beta chain. In mouse, CD122 is primarily expressed on natural killer (NK) cells and at lower levels on lymphocyte subsets, monocytes and macrophages.CD122 can associate with the IL-2R alpha chain (CD25) and CD132 to form a functional high affinity receptor complex that binds IL-2. CD132/CD122 heterodimers can also be formed which bind IL-2 with intermediate affinity. IL-2 binding to the IL-2R is important in the generation and differentiation of T lymphocytes and NK cells.Rat anti-Mouse CD122 antibody, clone TM-BETA 1 blocks IL-2 high affinity binding to the IL-2R beta receptor (Tanakaet al.1991). |
復(fù)溶 |
1. Tanaka, T. <i>et al.</i> (1991) A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells.</br>J Immunol. 147 (7): 2222-8. 2. Leung, K.T. <i.et al.</i> (2011) The tetraspanin CD9 regulates migration, adhesion, and homing of human cord blood CD34+ hematopoietic stem and progenitor cells.</br>Blood. 117: 1840-50. 3. Chenoweth, M.J. <i>et al.</i> (2012) IL-15 Can Signal via IL-15Rα, JNK, and NF-κB To Drive RANTES Production by Myeloid Cells.</br>J Immunol. 188: 4149-57.
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儲(chǔ)存溶液 |
Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, CD122, Il2rb
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