Store at +4°C or at -20°C.

Hamster anti-Mouse CD11c antibody, clone N418 recognizes the murine homolog of human CD11c, a 150/90 kDa member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells.Hamster anti-Mouse CD11c antibody, clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo(Wanget al.2000).

Hamster

1. Crowley, M.T. <i>et al.</i> (1990) Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen.</br>J Immunol Methods. 133 (1): 55-66. 2. Metlay, J.P. <i>et al.</i> (1990) The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.</br>J Exp Med. 171 (5): 1753-71. 3. Wang, H. <i>et al.</i> (2000) Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization.</br>Proc Natl Acad Sci U S A. 97 (2): 847-52. 4. Lundqvist, J. <i>et al.</i> (2010) Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis.</br>Infect Immun. 78 (5): 1924-30. 5. Beyer, M. <i>et al.</i> (2005) The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo.</br>Respir Res. 6: 70. 6. Goupil, M. <i>et al.</i> (2009) Macrophage-mediated responses to Candida albicans in mice expressing the human immunodeficiency virus type 1 transgene.</br>Infect Immun. 77: 4136-49. 7. Linehan, S.A.. (2005) The mannose receptor is expressed by subsets of APC in non-lymphoid organs.</br>BMC Immunol. 6:4. 8. Bjorck, P. (2004) Dendritic cells exposed to herpes simplex virus <em>in vivo</em> do not produce IFN-alpha after rechallenge with virus <em>in vitro</em> and exhibit decreased T cell alloreactivity.</br>J Immunol. 172: 5396-404. 9. Dahlen, E. <i>et al.</i> (1998) Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse.</br>J Immunol. 160: 3585-93. 10. de Jersey, J. <i>et al.</i> (2002) Activation of CD8 T cells by antigen expressed in the pituitary gland.</br>J Immunol. 169: 6753-9. 11. Dimier-Poisson, I. <i>et al.</i> (2003) Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells.</br>Infect Immun. 71: 5254-65. 12. Gonzalez-Juarrero, M. and Orme, I.M. (2001) Characterization of murine lung dendritic cells infected with <em>Mycobacterium tuberculosis</em>.</br>Infect Immun. 69: 1127-33. 13. Hamada, H. <i>et al.</i> (2002) Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine.</br>J Immunol. 168: 57-64. 14. Meng, Q. <i>et al.</i> (2007) Phenotypes, distribution, and morphological features of antigen-presenting cells in the murine cornea following intravitreal injection.</br>Mol Vis. 13: 475-86. 15. Mercier, S. <i>et al.</i> (2002) Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.</br>J Virol. 76: 2899-911. 16. Moos, M.P. <i>et al.</i> (2005) The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice</br>Arterioscler Thromb Vasc Biol. 25: 2386-91. 17. Nunez, R. <i>et al.</i> (1999) Immortalized cell lines derived from mice lacking both type I and type II IFN receptors unify some functions of immature and mature dendritic cells.</br>Immunol Cell Biol. 77: 153-63. 18. Ponce, L.V. <i>et al.</i> (2005) Adoptive transfer of dendritic cells modulates immunogenesis and tolerogenesis in a neonatal model of murine cutaneous leishmaniasis.</br>Kinetoplastid Biol Dis. 4: 2. 19. Zhang, L. <i>et al.</i> (2011) The inflammatory changes of adipose tissue in late pregnant mice.</br>J Mol Endocrinol. 47 (2): 157-65. 20. Donaldson, D.S. <i>et al.</i> (2012) M cell-depletion blocks oral prion disease pathogenesis.</br>Mucosal Immunol. 5: 216-25. 21. Wada, T. <i>et al.</i> (2013) Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet.</br>Am J Physiol Endocrinol Metab. 305 (11): E1415-25. 22. Kayser, B.D. <i>et al.</i> (2015) Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice.</br>PLoS One. 10 (3): e0121954. 23. Kan, M.J. <i>et al.</i> (2015) Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.</br>J Neurosci. 35 (15): 5969-82.

Mouse

Integrin alpha-X, CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, 95, CD11c, Itgax