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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > 單克隆抗體 > Anti-Mouse CD11a Antibody, clone I21/7 (RPE)

Anti-Mouse CD11a Antibody, clone I21/7 (RPE)

LM20012
貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)

Anti-Mouse CD11a Antibody, clone I21/7 (RPE)

品牌

Leading Biology

貨號(hào)

LM20012

產(chǎn)品分類(lèi)

單克隆抗體

研究領(lǐng)域

產(chǎn)品概述

Store at -20°C only.

濃度

Rat anti-Mouse CD11a antibody, clone I21/7 recognizes murine CD11a, a ~170-180kDa type I membrane glycoprotein, also known as the integrin alpha L subunit. CD11a is a member of the intergrin family of adhesion molecules. CD11a is expressed on all leucocytes and associates with CD18 to form a heterodimer at the cell surface. The CD11a/CD18 heterodimer binds to intercellular adhesion molecules (ICAM); ICAM1, ICAM-2 and ICAM-3 and is involved in cell-cell adhesion processes.Rat anti-Mouse CD11a antibody, clone I21/7 is reported to block the cytolytic activity of cytotoxic T cell lines (Trowbridge and Omary 1981).

純度

Rat

復(fù)溶

1. Trowbridge, I.S. & Omary, M.B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.</br>J Exp Med. 154 (5): 1517-24. 2. Champe, M. <i>et al.</i> (1995) Monoclonal antibodies that block the activity of leukocyte function-associated antigen 1 recognize three discrete epitopes in the inserted domain of CD11a.</br>J Biol Chem. 270 (3): 1388-94. 3. Campbell, S.B. <i>et al.</i> (2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells.</br>J Immunol. 167 (10): 5610-9. 4. Talento, A. <i>et al.</i> (1993) A single administration of LFA-1 antibody confers prolonged allograft survival.</br>Transplantation. 55 (2): 418-22. 5. Barrett, T.B. <i>et al.</i> (1991) CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.</br>J Immunol. 146 (6): 1722-9. 6. Kleinschnitz, C. <em>et al.</em> (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.</br>Blood. 121: 679-691 7. Falanga, P.B. & Butcher, E.C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model.</br>Eur J Immunol. 21 (9): 2259-63.1. Springer, T.A. <i>et al.</i> (1982) LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.</br>Immunol Rev. 68: 171-95.

儲(chǔ)存條件

Mouse

儲(chǔ)存溶液

Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, Lymphocyte antigen 15, Ly-15, CD11a, Itgal, Lfa-1, Ly-15

數(shù)量

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