產(chǎn)品描述 |
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Cellular_Location
Cytoplasm. Nucleus. Note=Excluded from the nucleoli
Tissue_Location
Ubiquitous. High expression in liver, spleen, pancreas and kidney
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