全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
LM21188 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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形式 |
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
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純度 |
Mouse |
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復(fù)溶 |
Friesen W.J.,et al.J. Biol. Chem. 277:8243-8247(2002).
Hosohata K.,et al.Mol. Cell. Biol. 23:7019-7029(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Yamada S.,et al.Oncogene 23:5901-5911(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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儲存條件 |
Human
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儲存溶液 |
Methylosome protein 50, MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50, WDR77, MEP50, WD45
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應(yīng)用 |
IHC-P (20 μg/ml)
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產(chǎn)品描述 |
Function
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Cellular_Location
Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors
Tissue_Location
Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.
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數(shù)量 |
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| 選擇 | 品牌 | 貨號 | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說明書 | 數(shù)量 | 目錄價 | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購 詢價 | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 單克隆抗體 | Chondrogenesis Markers |
|
￥4950.00 | 訂購 詢價 | |
| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 單克隆抗體 |
|
￥3243.00 | 訂購 詢價 | |||
| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 μl | 單克隆抗體 | Miscellaneous antibodies |
|
￥3243.00 | 訂購 詢價 | |
| 5 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 μl | 單克隆抗體 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 訂購 詢價 | |
| 6 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
|
￥5096.00 | 訂購 詢價 |
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