品牌 |
Leading Biology |
貨號 |
LM21053 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
This gene encodes a secreted, homodimeric glycoproteinthat is expressed in a wide variety of tissues and may haveautocrine or paracrine functions. The encoded protein has 10 of its15 cysteine residues conserved among stanniocalcin family membersand is phosphorylated by casein kinase 2 exclusively on its serineresidues. Its C-terminus contains a cluster of histidine residueswhich may interact with metal ions. The protein may play a role inthe regulation of renal and intestinal calcium and phosphatetransport, cell metabolism, or cellular calcium/phosphatehomeostasis. Constitutive overexpression of human stanniocalcin 2in mice resulted in pre- and postnatal growth restriction, reducedbone and skeletal muscle growth, and organomegaly. Expression ofthis gene is induced by estrogen and altered in some breastcancers.
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濃度 |
This STC2 monoclonal antibody is generated from mouse immunized with STC2 recombinant protein. |
純度 |
Mouse |
試劑準備 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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復溶 |
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Law, A.Y., et al. Exp. Cell Res. 316(3):466-476(2010)
Volland, S., et al. Int. J. Cancer 125(9):2049-2057(2009)
Ieta, K., et al. Int. J. Cancer 125(4):926-931(2009)
Tamura, K., et al. Cancer Sci. 100(5):914-919(2009)
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儲存條件 |
Human
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儲存溶液 |
Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2
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應用 |
WB~~1:100~250
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產(chǎn)品描述 |
Function
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Cellular_Location
Secreted.
Tissue_Location
Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes
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數(shù)量 |
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