品牌 |
Leading Biology |
貨號(hào) |
LM21039 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
|
產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
|
形式 |
Sialophorin (leukosialin) is a major sialoglycoprotein onthe surface of human T lymphocytes, monocytes, granulocytes, andsome B lymphocytes, which appears to be important for immunefunction and may be part of a physiologic ligand-receptor complexinvolved in T-cell activation.
|
濃度 |
This SPN/CD43 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 32-60 amino acids from the N-terminal region of human SPN/CD43. |
純度 |
Mouse |
試劑準(zhǔn)備 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
|
復(fù)溶 |
Urano-Tashiro, Y., et al. Infect. Immun. 76(10):4686-4691(2008)
Mambole, A., et al. J. Biol. Chem. 283(35):23627-23635(2008)
Seethala, R.R., et al. Appl. Immunohistochem. Mol. Morphol. 16(2):165-172(2008)
Khunkaewla, P., et al. Mol. Immunol. 45(6):1703-1711(2008)
Rawal, A., et al. Arch. Pathol. Lab. Med. 131(11):1673-1678(2007)
|
儲(chǔ)存條件 |
Human
|
儲(chǔ)存溶液 |
Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43
|
應(yīng)用 |
WB~~1:500~8000
|
產(chǎn)品描述 |
Function
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).
Cellular_Location
Membrane; Single-pass type I membrane protein
Tissue_Location
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas
|
數(shù)量 |
|