形式 |
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.
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復(fù)溶 |
The human WW45 protein enhances MST1-mediated apoptosis in vivo. Luo X, et al. Int J Mol Med, 2009 Mar. PMID 19212654.Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. Callus BA, et al. FEBS J, 2006 Sep. PMID 16930133.Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. Benzinger A, et al. Mol Cell Proteomics, 2005 Jun. PMID 15778465.The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Chan EH, et al. Oncogene, 2005 Mar 17. PMID 15688006.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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儲(chǔ)存溶液 |
Protein salvador homolog 1, 45 kDa WW domain protein, hWW45, SAV1, WW45
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