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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > 單克隆抗體 > RSK4 Antibody (N-term)

RSK4 Antibody (N-term)

LM20962
貨號 貨期 規(guī)格 / 價格 詢價

RSK4 Antibody (N-term)

品牌

Leading Biology

貨號

LM20962

產品分類

單克隆抗體

研究領域

產品概述

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

形式

RSK4 is a member of the family of 90-kDa ribosomal S6 kinases (1). These proteins are a class of serine/threonine kinases that are activated in response to various extracellular signals, including growth factors, polypeptide hormones and neurotransmitters (2). RSK4 is most abundantly expressed in brain and kidney. The predicted protein of 746 amino acids shows a high level of homology to three previously isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RSK4 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RSK4 plays a role in normal neuronal development (3).

濃度

A synthetic peptide corresponding to residues near the N-terminus of human Rsk 4 was used as an immunogen.

純度

Rabbit

試劑準備

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

復溶

1. Moller, D.E., et al. Am J Physiol. 266(2 Pt 1): 351<br>2. Frodin, M., et al. Mol. Cell. Endocrinol. 151: 65<br>3. Yntema HG, et al. Genomics 62(3):332-43, 1999.<br>

儲存條件

Human, Mouse

儲存溶液

Ribosomal protein S6 kinase alpha-6, S6K-alpha-6, 90 kDa ribosomal protein S6 kinase 6, p90-RSK 6, p90RSK6, Ribosomal S6 kinase 4, RSK-4, pp90RSK4, RPS6KA6, RSK4

應用

IHC~~1:50~100 WB~~1:1000~10000

產品描述

Function Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. Cellular_Location Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic

數(shù)量

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