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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > 單克隆抗體 > RASGRP4 Antibody (monoclonal) (M01)

RASGRP4 Antibody (monoclonal) (M01)

LM20922
貨號 貨期 規(guī)格 / 價格 詢價

RASGRP4 Antibody (monoclonal) (M01)

品牌

Leading Biology

貨號

LM20922

產(chǎn)品分類

單克隆抗體

研究領域

產(chǎn)品概述

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

形式

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. [provided by RefSeq]

濃度

RASGRP4 (NP_733748, 574 a.a. ~ 673 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

純度

mouse

試劑準備

Clear, colorless solution in phosphate buffered saline, pH 7.2.

復溶

1.Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras.Shalom-Feuerstein R, Makovski V, Levy R, Raz A, Kloog Y.Biochim Biophys Acta. 2008 Jun;1783(6):985-93. Epub 2008 Mar 25.

儲存條件

Human

儲存溶液

RAS guanyl-releasing protein 4, RASGRP4

應用

WB~~1:500~1000

數(shù)量

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