品牌 |
Leading Biology |
貨號 |
LM20876 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
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濃度 |
This RAB27A antibody is generated from a mouse immunized with a recombinant protein of human RAB27A. |
純度 |
Mouse |
試劑準(zhǔn)備 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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復(fù)溶 |
Seabra M.C.,et al.J. Biol. Chem. 270:24420-24427(1995).
Seabra M.C.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Chen D.,et al.Biochem. Mol. Med. 60:27-37(1997).
Tolmachova T.,et al.Gene 239:109-116(1999).
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
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儲存條件 |
Human
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儲存溶液 |
Ras-related protein Rab-27A, Rab-27, GTP-binding protein Ram, RAB27A, RAB27
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應(yīng)用 |
FC~~1:25
WB~~1:2000
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產(chǎn)品描述 |
Function
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Cellular_Location
Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles
Tissue_Location
Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
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數(shù)量 |
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