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當(dāng)前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > 單克隆抗體 > PTPN22 Antibody (monoclonal) (M01)

PTPN22 Antibody (monoclonal) (M01)

LM20863
貨號 貨期 規(guī)格 / 價格 詢價

PTPN22 Antibody (monoclonal) (M01)

品牌

Leading Biology

貨號

LM20863

產(chǎn)品分類

單克隆抗體

研究領(lǐng)域

產(chǎn)品概述

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

形式

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

濃度

PTPN22 (AAH17785, 1 a.a. ~ 179 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

純度

mouse

試劑準(zhǔn)備

Clear, colorless solution in phosphate buffered saline, pH 7.2.

復(fù)溶

Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years. Andersen MK, et al. Diabetes Care, 2010 Sep. PMID 20805278.Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis. Sfar I, et al. Arch Inst Pasteur Tunis, 2009. PMID 20707220.PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome. Bianco B, et al. Scand J Immunol, 2010 Sep. PMID 20696024.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population. Ban Y, et al. Thyroid, 2010 Aug. PMID 20615141.

儲存條件

Human

儲存溶液

Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP, PTPN22, PTPN8

應(yīng)用

WB~~1:500~1000

數(shù)量

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