全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
LM20853 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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產(chǎn)品概述 |
Store at -20°C.Stable for 12 months from date of receipt
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形式 |
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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純度 |
Mouse |
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試劑準(zhǔn)備 |
Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
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復(fù)溶 |
Brewis N.D.,et al.Biochim. Biophys. Acta 1171:231-233(1992).
Cohen P.T.W.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Hu M.C.-T.,et al.J. Biol. Chem. 273:33561-33565(1998).
Zhou G.,et al.J. Biol. Chem. 277:6391-6398(2002).
Mourtada-Maarabouni M.,et al.Cell Death Differ. 10:1016-1024(2003).
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儲(chǔ)存條件 |
Human
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儲(chǔ)存溶液 |
PP X;PP-X;PP4;PP4C;PP4C;PP4C_HUMAN;PPH3;PPP4;ppp4c;PPX;protein phosphatase 4 (formerly X), catalytic subunit;Protein phosphatase 4 catalytic subunit;Protein phosphatase X; Protein phosphatase X;protein phosphatase X, catalytic subunit;Serine/threonine protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 catalytic subunit.
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應(yīng)用 |
WB~~1:200
ICC~~1:200
IHC~~1:100
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產(chǎn)品描述 |
Function
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Cellular_Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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數(shù)量 |
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| 選擇 | 品牌 | 貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說明書 | 數(shù)量 | 目錄價(jià) | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購 詢價(jià) | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 單克隆抗體 | Chondrogenesis Markers |
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| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 單克隆抗體 |
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￥3243.00 | 訂購 詢價(jià) | |||
| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 μl | 單克隆抗體 | Miscellaneous antibodies |
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￥3243.00 | 訂購 詢價(jià) | |
| 5 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 μl | 單克隆抗體 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 訂購 詢價(jià) | |
| 6 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購 詢價(jià) |
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