形式 |
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified.
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復(fù)溶 |
The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression . Park S, et al. Biochemistry, 2010 Aug 10. PMID 20677832.Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Wang Z, et al. Cell, 2010 Jun 25. PMID 20541251.Use of genome-wide expression data to mine the Gray Zone of GWA studies leads to novel candidate obesity genes. Naukkarinen J, et al. PLoS Genet, 2010 Jun 3. PMID 20532202.Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. Hom RA, et al. J Mol Biol, 2010 Jul 9. PMID 20460131.Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Chen J, et al. Cancer Res, 2008 Aug 1. PMID 18676843.
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儲存溶液 |
Peptidyl-prolyl cis-trans isomerase E, PPIase E, Cyclophilin E, Cyclophilin-33, Rotamase E, PPIE, CYP33
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