品牌 |
Leading Biology |
貨號(hào) |
LM20818 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. ; ;
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純度 |
Mouse |
復(fù)溶 |
1. J Biol Chem. 2003 Mar 21;278(12):10657-67. 2. Biochemistry. 2003 Oct 7;42(39):11494-503.
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儲(chǔ)存條件 |
Human
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儲(chǔ)存溶液 |
Group XIIA secretory phospholipase A2, GXII sPLA2, sPLA2-XII, 3.1.1.4, Phosphatidylcholine 2-acylhydrolase 12A, PLA2G12A, PLA2G12
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應(yīng)用 |
E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
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產(chǎn)品描述 |
Function
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine.
Cellular_Location
Secreted. Cytoplasm
Tissue_Location
Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas
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數(shù)量 |
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