品牌 |
Leading Biology |
貨號 |
LM20720 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
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形式 |
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
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濃度 |
A synthetic peptide containing amino acid residues 96-113 of human kB-Ras1. |
純度 |
Mouse |
復(fù)溶 |
Fenwick C.,et al.Science 287:869-873(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chen Y.,et al.J. Biol. Chem. 278:23101-23106(2003).
Chen Y.,et al.Mol. Cell. Biol. 24:3048-3056(2004).
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儲(chǔ)存條件 |
Human, Mouse, Rat, Rabbit, Hamster, Monkey, Goat, Horse, Dog
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儲(chǔ)存溶液 |
NF-kappa-B inhibitor-interacting Ras-like protein 1, I-kappa-B-interacting Ras-like protein 1, Kappa B-Ras protein 1, KappaB-Ras1, NKIRAS1, KBRAS1
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應(yīng)用 |
IHC-P (5 μg/ml), WB (0.5-1 μg/ml),
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產(chǎn)品描述 |
Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Cellular_Location
Cytoplasm.
Tissue_Location
Widely expressed.
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數(shù)量 |
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