品牌 |
Leading Biology |
貨號 |
LM20675 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
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形式 |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
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濃度 |
Human MLKL |
純度 |
Mouse |
復(fù)溶 |
Manning G.,et al.Science 298:1912-1934(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
|
儲存條件 |
Human
|
儲存溶液 |
Mixed lineage kinase domain-like protein, hMLKL, MLKL {ECO:0000312|EMBL:AAH28141.1}
|
應(yīng)用 |
IHC-P (10 μg/ml)
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產(chǎn)品描述 |
Function
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Cellular_Location
Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction
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數(shù)量 |
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