全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
LM20611 |
產(chǎn)品分類 |
單克隆抗體 | 研究領域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
In the immune system, integrins have essential roles in leukocyte trafficking and function. These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues (1). Integrin adhesion receptors transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation and survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial for integrin-mediated signaling. JAB1 (Jun activation domain-binding protein 1), a coactivator of the c-Jun transcription factor, has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections (3).
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濃度 |
A synthetic phospho-peptide corresponding to residues surrounding Ser745 of human LFA-β2 was used as immunogen. The antibody only detects LFA-β2 phosphorylated on Serine 745. |
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純度 |
Rabbit |
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試劑準備 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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復溶 |
1. Kellersch B, et al. Results Prob Cell Differ 43:245-57, 2006<br>2. Bianchi E, et al. Nature 404(6778):617-21, 2000<br>3. Nelson C, et al. J. Biol Chem 267(5):3351-7, 1992.<br>
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儲存條件 |
Human, Mouse, Rat
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儲存溶液 |
Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7
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應用 |
WB~~1:5000~10000
IHC~~1:250~500
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產(chǎn)品描述 |
Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
Cellular_Location
Membrane; Single-pass type I membrane protein
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數(shù)量 |
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| 選擇 | 品牌 | 貨號 | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領域 | 說明書 | 數(shù)量 | 目錄價 | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購 詢價 | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 單克隆抗體 | Chondrogenesis Markers |
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￥4950.00 | 訂購 詢價 | |
| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 單克隆抗體 |
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￥3243.00 | 訂購 詢價 | |||
| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 μl | 單克隆抗體 | Miscellaneous antibodies |
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￥3243.00 | 訂購 詢價 | |
| 5 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 μl | 單克隆抗體 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 訂購 詢價 | |
| 6 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購 詢價 |
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